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Announcements

SARS-CoV-2 Variant Classifications and Definitions

Updated July 20, 2021

Key Points

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  • Genetic variants of SARS-CoV-2 have been emerging and circulating around the world throughout the COVID-19 pandemic.
  • Viral mutations and variants in the United States are routinely monitored through sequence-based surveillance, laboratory studies, and epidemiological investigations.
  • A US government SARS-CoV-2 Interagency Group (SIG) interagency group developed a Variant Classification scheme that defines three classes of SARS-CoV-2 variants:
  • The B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617.2 (Delta), and P.1 (Gamma) variants circulating in the United States are classified as variants of concern.
  • To date, no variants of high consequence have been identified in the United States.
  • Laboratory studies suggest specific monoclonal antibody treatments may be less effective for treating cases of COVID-19 caused by variants with certain substitutions or combinations of substitutions in the spike protein.
    • L452R is present in B.1.526 (Iota), B.1.427 (Epsilon), and B.1.429 (Epsilon) lineages, as well as the B.1.617 (Kappa, Delta) lineages and sub-lineages.
    • E484K is present in B.1.525 (Eta), P.2 (Zeta), P.1 (Gamma), and B.1.351 (Beta), but only some strains of B.1.526 (Iota) and B.1.1.7 (Alpha).
    • The combination of K417N, E484K, and N501Y substitutions is present in B.1.351 (Beta).
    • The combination of K417T, E484K, and N501Y substitutions is present in P.1 (Gamma).
  • P.2 (Zeta) has been removed from the variants of interest list due to declining prevalence and very few detections in recent months. In addition to variants of interest and variants of concern, CDC continues to monitor all variants circulating within the United States.

 

Viruses constantly change through mutation. A variant has one or more mutations that differentiate it from other variants in circulation. As expected, multiple variants of SARS-CoV-2 have been documented in the United States and globally throughout this pandemic. To inform local outbreak investigations and understand national trends, scientists compare genetic differences between viruses to identify variants and how they are related to each other.


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COVID-19 vaccine

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Statewide News

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Condolences

Passing of Past State Commander Joe Rigsby

Condolences

Passing of Department Quartermaster Dick Gardner

National News

Important info from National VFW

VFW Urges Navy to Honor Hero

WASHINGTON - In a letter sent to the Office of the Secretary of the U.S. Navy, Veterans of Foreign Wars (VFW) National Commander M...

A Haircut at Sport Clips or a Text Before Nov. 13 Can Help A Hero Go Back to School

GEORGETOWN, Texas - Sport Clips Haircuts kicks off its Help A Hero veteran scholarship campaign today to benefit scholarships for ...

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OUR MISSION

That the purpose of this Corporation shall be fraternal, patriotic, historical, charitable, and educational: to preserve and strengthen comradeship among its members; to assist worthy comrades; to perpetuate the memory and history of our dead; and to assist their widows and orphans; to maintain true allegiance to the Government of the United States of America, and fidelity to its Constitution and laws; to foster true patriotism; to maintain and extend the institutions of American freedom, and to preserve and defend the United States from all her enemies.
 
 

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