L452R is present in B.1.526 (Iota), B.1.427 (Epsilon), and B.1.429 (Epsilon) lineages, as well as the B.1.617 (Kappa, Delta) lineages and sub-lineages.
E484K is present in B.1.525 (Eta), P.2 (Zeta), P.1 (Gamma), and B.1.351 (Beta), but only some strains of B.1.526 (Iota) and B.1.1.7 (Alpha).
The combination of K417N, E484K, and N501Y substitutions is present in B.1.351 (Beta).
The combination of K417T, E484K, and N501Y substitutions is present in P.1 (Gamma).
P.2 (Zeta) has been removed from the variants of interest list due to declining prevalence and very few detections in recent months. In addition to variants of interest and variants of concern, CDC continues to monitor all variants circulating within the United States.
Viruses constantly change through mutation. A variant has one or more mutations that differentiate it from other variants in circulation. As expected, multiple variants of SARS-CoV-2 have been documented in the United States and globally throughout this pandemic. To inform local outbreak investigations and understand national trends, scientists compare genetic differences between viruses to identify variants and how they are related to each other.
Important Info for Post10047 Members
Basic information about getting your vaccine at VA